HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Chloro-7-(dimethylamino)quinoline-8-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3,7-Dichloroquinoline-8-carbonitrile | HCID 13090792 | — |
| Product | 3-Chloro-7-(dimethylamino)quinoline-8-carbonitrile | HCID 13206527 | 87% |
Reaction Steps
110 g of 3,7-dichloro-8-cyanoquinoline in 500 ml of dimethylformamide were refluxed for 20 hours, the solution was cooled, an amount of water corresponding to half the volume of the solution was added, and the precipitated solid was filtered off under suction. 100 g of 3-chloro-8-cyano-7-dimethylaminoquinoline of melting point 174° C. were obtained. Yield: 87% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04511393 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-6b03a166069e47e093193130619e182d |
| Source note | uspto-grants-1985_04 |