4-Methylmorpholine → HCID 13685962, compound

Participants

Reaction Steps

4.98 g (20 mmol) N-carbobenzoxy-L-proline, 2.73 g (20 mmol) isobutyl chloroformate, 2.02 g (20 mmol) N-methylmorpholine, and 2.73 g (26.5 mmol) L-valinol were contacted and reacted in THF, using a mixed anhydride procedure substantially as described in Example 1. The crude product, 5.93 g, was recrystallized from a mixture of 150 mL ethyl acetate and 250 mL n-hexane to give 5.24 g (15.7 mmol, 78%) of colorless N-carbobenzoxy-L-prolyl-L-valinol, m.p. 109.3°-110.7°, α25D -65.3°, (C=1.01 g/100 mL in acetone).

Provenance & Evidence