4-Methylmorpholine → HCID 13685967, compound

Participants

Reaction Steps

4.98 g (20 mmol) N-carbobenzoxy-L-proline, 2.73 g (20 mmol) isobutyl chloroformate, 2.02 g (20 mmol) N-methylmorpholine, and 1.50 g (20 mmol) L-alaninol were contacted and reacted in THF substantially according to the mixed anhydride procedure described in Example 1. Recrystallization of crude product from 50 ml ehtyl acetate provided 3.61 g (11.8 mmol, 59%) of colorless, crystalline N-carbobenzoxy-L-prolyl-L-alaninol; m.p. 126.5°-127.6°, α25D-48.9° (C=1.03 g/100 mL in acetone).

Provenance & Evidence