4-Methylmorpholine → HCID 13685985, compound

Participants

Reaction Steps

The subject compound was prepared from 0.85 g (2.98 mmol) p-chlorobenzyloxycarbonyl-L-proline, 0.41 g (2.98 mmol) isobutyl chloroformate, 0.30 g (2.97 mmol) N-methylmorpholine, and 0.31 g (2.98 mmol) L-valinol, substantially according to the mixed anhydride procedure described in Example 1. N-(p-chlorobenzyloxycarbonyl)-L-prolyl-L-valinol obtained after recrystallization from ethyl acetate/n-hexane melted at 143°-144.5°.

Provenance & Evidence