4-Methylmorpholine → HCID 13685987, compound

Participants

Reaction Steps

The subject compound was prepared from 3.9 g (14.8 mmol) p-methylbenzyloxycarbonyl-L-proline, 2.0 g (14.6 mmol) isobutyl chloroformate, 1.5 g (14.8 mmol) N-methylmorpholine, and 1.5 g (14.5 mmol) L-valinol, using a procedure described in Example 1. The product, N-(p-methylbenzyloxycarbonyl)-L-prolyl-L-valinol, obtained after recrystallization from ethyl acetate/ n-hexane, melted at 122°-123.5°, α25D -61.9° (C=1.00 g/100 mL in acetone).

Provenance & Evidence