HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Acetylphenyl)acetamide → N-[2-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Acetylphenyl)acetamide | HCID 21306 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-[2-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]acetamide | HCID 54331422 | 63.6% |
Reaction Steps
A suspension of 48 g of N-[2-(1-oxo-1-ethanyl)phenyl]acetamide and 38 g of N,N-dimethylformamide dimethyl acetal in 150 ml of toluene was heated at reflux for about 16 hours, then concentrated in vacuo to a solid. The solid was recrystallized from 1-chlorobutane to yield 40 g of the title compound; m.p. 90°-95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04511392 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-91981f3b007648329364ff0ba5a4d039 |
| Source note | uspto-grants-1985_04 |