Sulfuric Acid → HCID 10631790, compound

HRID 1980815Notes

Reaction equation

HRID 1980815 reaction equation
S(=O)(=O)(O)O.C([C:8]1[C:9](=[O:22])[NH:10][C:11]2[CH2:12][CH2:13][C:14]3[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=3[C:16]=2[CH:17]=1)#N.[OH-].[Na+]>O>[CH:17]1[C:16]2[C:15]3[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=3[CH2:13][CH2:12][C:11]=2[NH:10][C:9](=[O:22])[CH:8]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 20400737HCID 20400737, compound

Product 1

HCID 10631790HCID 10631790, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 60 ml of concentrated sulfuric acid and 15 ml of water, add 22.2 gm of 2-cyano-5,6-dihydrobenzo[f]quinolin-3(4H)-one. Heat the system at reflux for 24 hours. Cool the system and pour the solution into 1 liter of ice/water. Neutralize the solution with 10N NaOH solution. Extract the solution with 300 ml of chloroform and dry the organic solution over anhydrous magnesium sulfate. Filter the solution and remove the solvent by stripping to give the title compound.

Workup

  1. temperatureHeat the system
  2. temperatureat reflux for 24 hours
  3. temperatureCool the system
  4. extractionExtract the solution with 300 ml of chloroform
  5. dry with materialdry the organic solution over anhydrous magnesium sulfate
  6. filtrationFilter the solution
  7. customremove the solvent

Sources & evidence

ORD record
ord-79681adf838c4377a8eaa6aa8c15d0e6
Source dataset
uspto-grants-1985_04
Patent number
US04511569

Reaction notes

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