HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → 3-(4-Carboxybutyl)-2-(3-pyridyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(4-Cyanobutyl)-2-(3-pyridyl)indole | HCID 20400797 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(4-Carboxybutyl)-2-(3-pyridyl)indole | HCID 20400793 | — |
Reaction Steps
3-(4-Cyanobutyl)-2-(3-pyridyl)-indole (540 mg) is heated at 185° for 0.5 hour with 450 mg of powdered NaOH and 5 ml of ethylene glycol; the reaction solution is diluted with 50 ml water, washed with ether, and adjusted to pH 6 with 2N HCl, to give 3-(4-carboxybutyl)-2-(3-pyridyl)indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04511573 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-e18af54c27034d5fb21452734b444fff |
| Source note | uspto-grants-1985_04 |