HCID 54337531, compound → HCID 13424126, compound

Participants

Reaction Steps

A solution of 3-(5-carboxypent-1-enyl)-1-methyl-2-(3-pyridyl)indole (0.51 g) in absolute ethanol (20 ml), to which is added 10% Pd/C (0.05 g), is hydrogenated at 3 atmospheres pressure for 2 hours. The catalyst is removed by filtration and the filtrate concentrated to dryness. Trituration of the residue with absolute ethanol gives a while solid, m.p. 117°-120°. Recrystallization from acetonitrile yields 1-methyl-2-(3-pyridyl)-3-(5-carboxypentyl)indole (the compound of Example 3), m.p. 128°-130°.

Provenance & Evidence