HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(4-Chlorophenylthio)pyrrole-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-(4-chlorophenylthio)pyrrole-3-carboxylate | HCID 12897034 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(4-Chlorophenylthio)pyrrole-3-carboxylic Acid | HCID 12897035 | — |
Reaction Steps
Methyl 5-(4-chlorophenylthio)pyrrole-3-carboxylate (1.4 g.) was combined with 20 ml. of methanol and 20 ml. of 1N sodium hydroxide and heated on a steam bath for 2 hours. The reaction was cooled, acidified with conc. hydrochloric acid. and the crude product which precipitated, collected by filtration. Two recrystallizations from acetone/hexane afforded purified 5-(4-chlorophenylthio)pyrrole-3-carboxylic acid (740 mg., m.p. 171°-173° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04511576 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-82ecab0a366a4ff4976e2e9f6b503c12 |
| Source note | uspto-grants-1985_04 |