Sodium Hydroxide → 5-(3,4-Dichlorophenylthio)pyrrole-3-carboxylic Acid

HRID 1980982Notes

Reaction equation

HRID 1980982 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[NH:14][CH:13]=[C:12]([C:15]([O:17]C)=[O:16])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[NH:14][CH:13]=[C:12]([C:15]([OH:17])=[O:16])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12897048Methyl 5-(3,4-Dichlorophenylthio)pyrrole-3-carboxylate

Product 1

HCID 128970395-(3,4-Dichlorophenylthio)pyrrole-3-carboxylic Acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methyl 5-(3,4-dichlorophenylthio)pyrrole-3-carboxylate (1.7 g.) was combined with 20 ml. of methanol and 20 ml. of 1N sodium hydroxide and refluxed for 3 hours. The methanol was allowed to evaporate, and approximately one volume of water was added to the aqueous residue, which was then extracted twice with ether, cooled in an ice-water bath, acidified with conc. hydrochloric acid, and the product extracted into ethyl acetate. The three ethyl acetate extracts were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and evaporated in vacuo to a gummy solid which was crystallized by trituration with hexane and recovered by filtration (1.34 g., m.p. 156°-159° C.). Recrystallization from chloroform gave purified 5-(3,4-dichlorophenylthio)pyrrole-3-carboxylic acid (850 mg., m.p. 159°-161° C.).

Workup

  1. customto evaporate
  2. additionapproximately one volume of water was added to the aqueous residue, which
  3. extractionwas then extracted twice with ether
  4. temperaturecooled in an ice-water bath
  5. extractionthe product extracted into ethyl acetate
  6. washwashed with saturated brine
  7. dry with materialdried over anhydrous sodium sulfate
  8. filtrationfiltered
  9. customevaporated in vacuo to a gummy solid which
  10. customwas crystallized by trituration with hexane
  11. filtrationrecovered by filtration (1.34 g., m.p. 156°-159° C.)
  12. customRecrystallization from chloroform
  13. customgave
  14. custompurified 5-(3,4-dichlorophenylthio)pyrrole-3-carboxylic acid (850 mg., m.p. 159°-161° C.)

Sources & evidence

ORD record
ord-375b2929d26e4cd4895ab45bb631f3ee
Source dataset
uspto-grants-1985_04
Patent number
US04511576

Reaction notes

Loading…