Sodium Hydroxide → HCID 12897055, compound

HRID 1980997Notes

Reaction equation

HRID 1980997 reaction equation
[C:1]([C:9]1[NH:13][CH:12]=[C:11]([C:14]([O:16]C)=[O:15])[CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[C:1]([C:9]1[NH:13][CH:12]=[C:11]([C:14]([OH:16])=[O:15])[CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12897054HCID 12897054, compound

Product 1

HCID 12897055HCID 12897055, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Methyl 5-benzoylpyrrole-3-carboxylate (7.5 g.) was combined with 100 ml. of 1N sodium hydroxide and 100 ml. of ethanol and boiled in an open flask for 1 hour, by which time most of the ethanol had evaporated. The aqueous residue was diluted with 100 ml. of water and acidified with conc. hydrochloric acid to precipitate crystalline 5-benzoylpyrrole-3-carboxylic acid [6.3 g., m.p. 289°-290° C. (dec.), m/e 215].

Workup

  1. customhad evaporated
  2. additionThe aqueous residue was diluted with 100 ml
  3. customto precipitate crystalline 5-benzoylpyrrole-3-carboxylic acid [6.3 g., m.p. 289°-290° C. (dec.), m/e 215]

Sources & evidence

ORD record
ord-57d719be67c846829c918545711c2324
Source dataset
uspto-grants-1985_04
Patent number
US04511576

Reaction notes

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