Formic Acid → N-Pyridin-2-ylmethyl-formamide

HRID 1981040Notes

Reaction equation

HRID 1981040 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[CH:9](O)=[O:10]>>[CH:9]([NH:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)=[O:10]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 195092-Pyridinemethanamine

Product 1

HCID 12228441N-Pyridin-2-ylmethyl-formamide

Procedure

2-Aminomethylpyridine (60 g.) was refluxed with 180 ml. of formic acid for 4 hours and left to stir for approximately 16 hours at room temperature. The reaction mixture was concentrated to an oil and purified; 2-formamidomethylpyridine obtained by distillation (72.3 g., b.p. 117°-141° C./0.5 mm.)

Workup

  1. waitleft
  2. concentrationThe reaction mixture was concentrated to an oil
  3. custompurified

Sources & evidence

ORD record
ord-ab1b352a26db4370a11f54d3e7d9d065
Source dataset
uspto-grants-1985_04
Patent number
US04511576

Reaction notes

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