反应详情

Into a flask equipped with a stirrer and a thermometer, dl-2-allyl-3-hydroxy-3-methyl-4-cyclopentenone (30.4 g), pyridine (30 g) and dichloromethane (300 g) were charged, and acetyl chloride (30 g) was dropwise added thereto at a temperature from 10° to 20° C. in 2 hours. Then, stirring was continued at a room temperature for 24 hours. To the reaction mixture kept below 10° C., water (100 ml) was added to decompose excess of acetyl chloride. From the resultant mixture, the organic layer was separated and washed with 1% hydrochloric acid, 1% sodium bicarbonate solution and water in order. Removal of the solvent by distillation gave dl-3-acetoxy-2-allyl-3-methyl-4-cyclopentenone (36.5 g). Yield, 94%.

1. customInto a flask equipped with a stirrer
2. waitwas continued at a room temperature for 24 hours
3. customkept below 10° C.
4. customFrom the resultant mixture, the organic layer was separated
5. washwashed with 1% hydrochloric acid, 1% sodium bicarbonate solution and water in order
6. customRemoval of the solvent
7. distillationby distillation