Pyridine → HCID 13517254, compound

Participants

Reaction Steps

Into the same flask as in Example 1, dl-2-allyl-3-hydroxy-3-methyl-4-cyclopentenone (15.2 g), pyridine (15 g) and dichloromethane (150 g) were charged, and chloroacetyl chloride (22.5 g) was dropwise added thereto at a temperature from 10° to 15° C. in 3 hours. Then, stirring was continued at room temperature for 24 hours. To the reaction mixture kept below 10° C., water (50 ml) was added to decompose excess of acetyl chloride. The resulting mixture was treated as in Example 1. The residue was purified by silica gel chromatography using a mixture of toluene and ethyl acetate (10:1) as an eluent to give dl-2-allyl-3-chloroacetyloxy-3-methyl-4-cyclopentenone (20.7 g). Yield, 91%.

Provenance & Evidence