Sodium hydride → HCID 13424017, compound

Participants

Reaction Steps

Ethyl 1-(2-iodoethyl)-3-carboethoxy-4-methyl-pyrrole-2-acetate in 65 ml of dry dimethylformamide was treated with 1.6 g NaH (60% in mineral oil) and stirred for 60 minutes at room temperature. The mixture was quenched with 100 ml of water and extracted with ethylacetate (3×100 ml). The ethyl acetate layer was washed with water, dried over MgSO4, filtered and evaporated to dryness to yield 6.4 g of crude diethyl 1,2-dihydro-6-methyl-3H-pyrrolo-[1,2-a]pyrrole-1,7-dicarboxylate to be used in the next step without further purification.

Provenance & Evidence