Sodium Hydroxide → HCID 86740030, compound

Participants

Reaction Conditions

Reaction Steps

400 parts of 3,4-dimethoxycarbonyl-8-(4-chlorophenyl)-12-t-butoxy-3,4,8,9,10-pentazatetracyclo[5,4,1,02,5,07,11 ]dodec-9-ene (Compound No. 9) were suspended in 1,000 parts of 25 percent strength aqueous sodium hydroxide solution, and the suspension was stirred for 6 hours at 85° C. Thereafter, 1,150 parts of 13 percent strength aqueous NaOCl were added at 60° C. in the course of 2 hours, and stirring was continued for 4 hours at 60° C. The mixture was cooled to 20° C., after which the solid product was filtered off under suction, washed with 3,000 parts of water and dried at 30° C. under 1 mbar. 270 parts (96 mole %) of 8-(4-chlorophenyl)-12-t-butoxy-3,4,8,9,10-pentazatetracyclo[5,4,1,02,5,07,11 ]dodeca-3,9-diene of melting point 178° C. (decomposition) were obtained (Compound No. 2). ##STR21##

Provenance & Evidence