Phthalic Anhydride → (2S)-5-(Benzyloxy)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoic acid

HRID 1981113Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1981113
[CH:1]1[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]([CH2:11][CH2:12][C@H:13]([NH2:17])[C:14]([OH:16])=[O:15])=[O:10])=[CH:3][CH:2]=1.[C:18]1(=O)[O:23][C:21](=[O:22])[C:20]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:19]12>C1(C)C=CC=CC=1>[CH2:7]([O:8][C:9]([CH2:11][CH2:12][C@H:13]([N:17]1[C:21](=[O:22])[C:20]2[C:19](=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:18]1=[O:23])[C:14]([OH:16])=[O:15])=[O:10])[C:4]1[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=1

Komponenten

4

Edukt 2

HCID 6811Phthalic AnhydrideHCID 122337L-Glutamic acid, 5-(phenylmethyl) ester

Produkt 1

HCID 11100670(2S)-5-(Benzyloxy)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoic acidAusbeute 60,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

16 g of L-glutamic acid γ-benzyl ester and 11 g of phthalic anhydride, both finely powdered, were stirred in 20 ml of toluene at reflux temperature for 2 hours. 50 ml of toluene were added and the mixture was evaporated. A further 80 ml of toluene were then added and the mixture was left to crystallize. Recrystallization from toluene yielded 15 g of α(S)-(2-benzyloxycarbonylethyl)-1,3-dihydro-1,3-dioxo-2-isoindoleacetic acid of melting point 96°-98° C.; [α]D20 =-50.4° (c=1 in methanol).

Aufarbeitung

  1. temperatureat reflux temperature for 2 hours
  2. customthe mixture was evaporated
  3. additionA further 80 ml of toluene were then added
  4. waitthe mixture was left
  5. customto crystallize
  6. customRecrystallization from toluene

Quellen und Nachweise

ORD-Eintrag
ord-3cda9f894ba44acab2440abae356a481
Quelldatensatz
uspto-grants-1985_04
Patentnummer
US04512924

Notizen zur Reaktion

Wird geladen…