2-Oxo-4-phenylbutyric acid → HCID 18597374, compound

HRID 1981114Notes

Reaction equation

HRID 1981114 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]2[C@H:10]([C:13]([OH:15])=[O:14])[CH2:11][CH2:12][N:6]2[C:5](=[O:16])[CH2:4][CH2:3]1.O=[C:18]([CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:19]([OH:21])=[O:20]>>[C:19]([CH:18]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]2[C@H:10]([C:13]([OH:15])=[O:14])[CH2:11][CH2:12][N:6]2[C:5](=[O:16])[CH2:4][CH2:3]1)[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([OH:21])=[O:20]

Participants

3

Reactant 2

HCID 697322-Oxo-4-phenylbutyric acidHCID 18597382HCID 18597382, compound

Product 1

HCID 18597374HCID 18597374, compoundYield 18.1%

Procedure

In a manner analogous to that described in the first paragraph of Example 1, from 1.13 g of 8(S)-amino-2,3,6,7,8,9-hexahydro-5,9-dioxo-1H,5H-pyrazolo[1,2-a][1,2]diazepine-1(S)-carboxylic acid and 2.7 g of 2-oxo-4-phenylbutyric acid there were obtained 350 mg of 8(S)-(1-carboxy-3-phenylpropylamino)-2,3,6,7,8,9-hexahydro-5,9-dioxo-1H,5H-pyrazolo[1,2-a][1,2]diazepine-1(S)-carboxylic acid in the form of a lyophilized mixture.

Sources & evidence

ORD record
ord-b46401cc0e5c4815a4e316e723ce4694
Source dataset
uspto-grants-1985_04
Patent number
US04512924

Reaction notes

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