Sodium Hydroxide → HCID 86740034, compound

HRID 1981143Notes

Reaction equation

[C:1]([NH:9][CH:10]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:11](=[O:32])[CH2:12][NH:13][CH:14]1[C:20](=[O:21])[N:19]([CH2:22][C:23]([O:25]CC)=[O:24])[CH:18]2[CH2:28][CH:29]=[CH:30][CH:31]=[C:17]2[S:16][CH2:15]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>>[C:1]([NH:9][CH:10]([CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)[C:11](=[O:32])[CH2:12][NH:13][CH:14]1[C:20](=[O:21])[N:19]([CH2:22][C:23]([OH:25])=[O:24])[CH:18]2[CH2:28][CH:29]=[CH:30][CH:31]=[C:17]2[S:16][CH2:15]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86740035HCID 86740035, compound

Product 1

HCID 86740034HCID 86740034, compound

Procedure

The ester product from part (f) is treated with 1N sodium hydroxide according to the procedure of Example 29(h) to yield (±)-dihydro-3-[[3-(benzoylamino)-2-oxo-4-phenylbutyl]amino]-4-oxo-1,5-benzothiazepine-5(2H)-acetic acid.

Sources & evidence

ORD record: ord-3840e335cbd04bcfa4e186ebdce65172
Source dataset: uspto-grants-1985_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04512988

Reaction notes

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