Hydrogen Bromide → HCID 18597442, compound

Participants

Reaction Steps

Compound 3 was then hydrolyzed with 30% hydrogen bromide in glacial acetic acid. After purification over LH-20 with methanol, 0.054 g. (25%) of N-[S-(2-aminoethyl)-N-(1-carboxy-3-phenylpropyl)-L-homocysteinyl]-1,2,3,4-tetrahydroisoquinoline-3-(S)-carboxylic acid was obtained; a white solid after freeze drying; nmr (CO3OD): δ2.1-2.25 (m, 4H, aromatic CH2CH2 --, --SCH2CH2CH<), 2.7-2.9 (m, 8H, aromatic CH2CH2 --, aromatic CH2CH<--CH2S--CH2 --), 3.0-3.25 (m, 2H, --SCH2CH2NH2), 3.32 (S, 2H, aromatic CH2N<), 3.5-3.8 (m, 1H, NCHRCO2 --), 7.2.-7.3 (m, 4H, aromatic), ms: M+ 463.

Provenance & Evidence