Acetone → HCID 57109743, compound

HRID 1981161Notes

Reaction equation

HRID 1981161 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]([OH:12])[CH2:9][CH:10]=[CH2:11])=[N:6][C:5]([Cl:13])=[C:4]([Cl:14])[N:3]=1.C[C:16](C)=[O:17]>[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[C:7]([C:8](=[O:12])[CH2:9][CH:10]=[CH:11][CH:16]=[O:17])=[N:6][C:5]([Cl:13])=[C:4]([Cl:14])[N:3]=1

Participants

4

Reactant 2

HCID 180AcetoneHCID 20399874HCID 20399874, compound

Product 1

HCID 57109743HCID 57109743, compound

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

In 8 ml of acetone there was dissolved 2-amino-5,6-dichloro-3-(1-hydroxy-3-butenyl)pyrazine (120 mg) prepared in Step A above, after which there was added manganese dioxide (480 mg), followed by stirring for 6 hours at room temperature. The manganese dioxide was then filtered, the precipitate washed well with acetone, and the filtrate concentrated. The remaining material was then passed through a silica gel column and eluted with dichloromethane to give the product (23 mg).

Workup

  1. filtrationThe manganese dioxide was then filtered
  2. washthe precipitate washed well with acetone
  3. concentrationthe filtrate concentrated
  4. washeluted with dichloromethane

Sources & evidence

ORD record
ord-a7fc1c88dffc4f608f60c6cb575e8586
Source dataset
uspto-grants-1985_04
Patent number
US04512991

Reaction notes

Loading…