反应详情

In 2 ml of acetone there was dissolved 2-amino-5,6-dichloro-3-[hydroxy(thiazol-2-yl)methyl]-pyrazine (44 mg) prepared in Step C above, after which manganese dioxide (120 mg) was added, and the reaction mixture was stirred for 5 hours at room temperature. The manganese dioxide was filtered off, the remaining precipitate washed twice with acetone, and the filtrate concentrated to dryness to give a crystalline product (29 mg).

1. additionwas added
2. filtrationThe manganese dioxide was filtered off
3. washthe remaining precipitate washed twice with acetone
4. concentrationthe filtrate concentrated to dryness