HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Methoxybenzyl 2-bromoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Methoxybenzyl alcohol | HCID 7738 | — |
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | Calcium Chloride | HCID 5284359 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Methoxybenzyl 2-bromoacetate | HCID 13233234 | — |
Reaction Steps
20.2 g (0.1 mol) of bromoacetyl bromide are dissolved in 100 ml of toluene, this solution is cooled to -10° C. (CaCl2 tube) and 8.7 g (0.11 mol) of pyridine are added dropwise at -10° C. Thereafter, 13.8 g (0.1 mol) of 4-methoxybenzyl alcohol, dissolved in 20 ml of toluene are added dropwise to this mixture in the course of 20 minutes at -10° C., and the mixture is allowed to react for 1 hour at this temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04513004 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-5daf8af4fbfd450892b0c994d83359d4 |
| Source note | uspto-grants-1985_04 |