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HRID1981204

反应详情

EQUATION

反应方程式

HRID 1981204 的结构方程式

REACTANTS

反应物

2
结构：c1ccccc1
HCID241

Benzene

C6H6

结构：C=S1C2C(=O)C(=O)N2C(C(=O)O)C1(C)C.CC(C)(C)C(=O)O
HCID86740043

未命名化合物

PRODUCTS

生成物

1
结构：C=S1[C@@H]2C(=C(C)C(C)=O)C(=O)N2[C@@H](C(=O)O)C1(C)C.CC(C)(C)C(=O)O
HCID86740049

未命名化合物

PROCEDURE

实验过程

A solution of 7.8 g of methylene-6,7-dioxo-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate pivalate in 200 ml of benzene is treated at room temperature with 10 g of triphenylphosphinemethylacetylmethylene. After 10 minutes, the reaction mixture is evaporated. The residue is chromatographed on silica gel while eluting with cyclohexane/ethyl acetate (6:4). There is obtained methylene-(2S,5R)-3,3-dimethyl-6-(1-methyl-2-oxopropylidene)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate pivalate as white crystals of melting point 59°-60° [Rf: 0.30; cyclohexane/ethyl acetate (6:4)].

WORKUP

后处理

  1. customthe reaction mixture is evaporated
  2. customThe residue is chromatographed on silica gel
  3. washwhile eluting with cyclohexane/ethyl acetate (6:4)