Sodium Hydroxide → HCID 15580536, compound

Participants

Reaction Steps

2 g N-[(S)-2-benzoylthio-3-phenyl-propionyl]-L-leucine dissolved in 10 ml MeOH are stirred at 0° C. for 1 hour with 10 ml 1N NaOH, and then for 4 hours at 25° C. under a nitrogen atmosphere. The methanol is evaporated off, the material is taken up into water and made acidic to pH 1 with 1N HCl. The resulting gummy precipitate is extracted with ethyl acetate. The organic phase is dried, and evaporated in vacuo, to give 1.45 g N-[(S)-2-mercapto-3-phenyl-propionyl]-L-leucine which crystallizes slowly. M.P.=67°-71° C.

Provenance & Evidence