Acetic Acid → D-Leucine

HRID 1981241Notes

Reaction equation

HRID 1981241 reaction equation
Cl.C([NH:9][C@@H:10]([C:15]([OH:17])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])C1C=CC=CC=1.C(O)(=O)C>[Pd].CO>[NH2:9][C@@H:10]([C:15]([OH:17])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13]

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 67908467HCID 67908467, compound

Product 1

HCID 439524D-Leucine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 0.5 g of benzyl D-leucine hydrochloride, 20 ml of acetic acid and 20 ml of methanol was stirred with palladium under a hydrogen atmosphere until absorption ceased and the mixture was filtered. The filtrate was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel to obtain D-leucine.

Workup

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated to dryness under reduced pressure
  3. customthe residue was chromatographed over silica gel

Sources & evidence

ORD record
ord-cfa06c0bfe4d47d9b42357dfb7ef6a84
Source dataset
uspto-grants-1985_04
Patent number
US04513139

Reaction notes

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