Potassium Bicarbonate → HCID 70479998, compound

HRID 1981289Notes

Reaction equation

HRID 1981289 reaction equation
Cl.[NH2:2][C@H:3]([C:8]([NH:10][C@@H:11]([C:16]([NH:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH:34]1[CH:41]2[CH2:42][CH:37]3[CH2:38][CH:39]([CH2:43][CH:35]1[CH2:36]3)[CH2:40]2)=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21])=[O:17])[CH2:12][CH2:13][S:14][CH3:15])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].C(=O)(O)[O-].[K+]>O>[NH2:2][C@H:3]([C:8]([NH:10][C@@H:11]([C:16]([NH:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH:34]1[CH:41]2[CH2:42][CH:37]3[CH2:38][CH:39]([CH2:43][CH:35]1[CH2:36]3)[CH2:40]2)=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21])=[O:17])[CH2:12][CH2:13][S:14][CH3:15])=[O:9])[CH2:4][CH:5]([CH3:6])[CH3:7]

Participants

4

Reactant 2

HCID 516893Potassium BicarbonateHCID 70481357HCID 70481357, compound

Product 1

HCID 70479998HCID 70479998, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title product of Example 2 is stirred under argon in water containing a molar excess of potassium bicarbonate. After about one hour the mixture is extracted with dichloromethane, and the organic layer is dried over sodium sulfate, filtered, and concentrated in vacuo to produce the title compound as the free base.

Workup

  1. extractionAfter about one hour the mixture is extracted with dichloromethane
  2. dry with materialthe organic layer is dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2753699892c443809007ef6ad17d5dd8
Source dataset
uspto-grants-1985_04
Patent number
US04514332

Reaction notes

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