Isopropanol → HCID 7083849, compound

Participants

Reaction Steps

A mixture of 28.6 g of 6-chloro-9(β-D-ribofuranosyl)-purine, 14.2 g of o-chlorobenzyl amine, 400 ml of dimethylformamide, 400 ml of isopropanol and 50 ml of triethylamine is left to stand at 20° for 4 days. The mixture is evaporated, the residue is dissolved in chloroform, the chloroform solution is washed with 1% aqueous acetic acid and evaporated again and the residue is triturated with ether to give N6 -o-chlorobenzyl-adenosine (Ia). M.p.: 182°-183°.

Provenance & Evidence