Piperazine → HCID 20399356, compound

Participants

Reaction Steps

In to a solution consisting of 6.7 g of 6-(α-chloroacetyl)-3,4-dihydrocarbostyril and 60 ml of anhydrous dimethylformamide was added 4.4 g of piperazine and 5 ml of triethylamine and the reaction mixture was stirred at 50° to 60° C. for 1 hour. The reaction mixture thus obtained was poured into a large amount of water and was extracted with chloroform. The chloroform layer was washed with water, dried and chloroform was removed by distillation. The residue obtained was suspended in a mixture of methanol-chloroform and by adding hydrochloric acid/methanol to obtain 3.5 g of 6-(1-piperazinyl)acetyl-3,4-dihydrocarbostyril monohydrochloride trihydrate in the form of colorless needle-like crystals. Melting point: 265°-267° C. (decomposed).

Provenance & Evidence