Dichloromethane → HCID 13340644, compound

Participants

Reaction Steps

To a suspension of 8.3 g (0.02 m) of 4,10-dihydro-N-(1-hydroxy-2-methyl-2-propyl)-10-oxothieno[3,2-c][1]benzoxepin-8-yl acetamide of Example 1 and 200 ml of methylene chloride, SOCl2 (3.09 g) was added dropwise keeping the temperature at approximately 5° C. The suspended material gradually dissolved. The mixture was stirred overnight (about 16 hours). The organic layer was washed with 10% NaOH, dried (Na2SO4) and evaporated to give an oil. Trituration with isopropyl ether gave 4.1 g (52%) of 2-(4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-yl)methyl-4,4-dimethyl-oxazoline, m.p. 85°-87° C.

Provenance & Evidence