Sodium Hydroxide → HCID 20399489, compound

HRID 1981331Notes

Reaction equation

HRID 1981331 reaction equation
[C:1]1([C:7]#[C:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17]([O:19]C)=[O:18])[CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([C:7]#[C:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17]([OH:19])=[O:18])[CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54012668HCID 54012668, compound

Product 1

HCID 20399489HCID 20399489, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The ester (0.0126 mole) is hydrolyzed in 200 ml. of methanol and 25 ml. of 1.0 N sodium hydroxide (0.025 mole), treated with 13 ml. of 1.0 N hydrochloric acid, evaporated and the residue is recrystallized to give 1-(4-phenyl-3-butynyl)-3-pyrrolidineacetic acid.

Workup

  1. customof 1.0 N hydrochloric acid, evaporated
  2. customthe residue is recrystallized

Sources & evidence

ORD record
ord-a133cb55f9d2463baa6df6c99fea1531
Source dataset
uspto-grants-1985_04
Patent number
US04514414

Reaction notes

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