HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 20399406, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,4-dimethyl-1H-pyrrole-1-propan-1-ol | HCID 12894118 | — |
| Reactant | (2-Chloropyridin-4-yl)(piperidin-1-yl)methanone | HCID 18771703 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 20399406 | HCID 20399406 | 102.5% |
Reaction Steps
To a suspension of 0.047 mol of 2.5-dimethyl-1-(3-hydroxypropyl)pyrrole and 0.059 mol of 80% sodium hydride in 150 ml of 1,2-dimethoxyethane, previously heated at reflux for 15 minutes and cooled, is added 0.044 mol of 2-chloro-4-piperidino carbonylpyridine, then the reaction mixture is heated two hours with reflux and evaporated to dryness. The residue is taken up with water and extracted with ethyl acetate. The organic phase is separated and evaporated to dryness. Thus, 15.4 g of an oily product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04514408 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-fff140c4919a4331b0708ce900434650 |
| Source note | uspto-grants-1985_04 |