5-(4-Nitrophenyl)pyrazin-2(1H)-one → 5-(4-Aminophenyl)pyrazin-2(1H)-one

Participants

Reaction Steps

5-(4-Nitrophenyl)-2-(1H)-pyrazinone (0.1 g) was hydrogenated over 10% Palladium on Charcoal (0.01 g) at atmospheric pressure in 50% aqueous dimethylformamide containing 2N sodium hydroxide (0.46 ml). Once the theoretical quantity of hydrogen uptake had been observed, the reaction mixture was filtered and the filtrate treated with HCl to pH 6 and evaporated. Trituration of the residue with water afforded 5-(4-aminophenyl)-2(1H)-pyrazinone (0.07 g), m.p. 269°-271.5° C. (with decomposition).

Provenance & Evidence