Ammonia → HCID 54394851, compound

Participants

Reaction Conditions

Reaction Steps

The procedures of Examples 1 and 2 are followed without isolation of the intermediate phosphonate of formula (III). The reaction solution resulting from the Wittig reaction of Example 2 is cooled to -78° C. and the procedure of Example 4 is followed with the addition of ammonia followed by 15 molar equivalents each of tert-butanol and lithium metal. The solution is refluxed at -33° C. for no more than 15 minutes and is then worked up as in Example 4 to yield the hexahydro-isoquinoline derivative of formula (X) wherein R4 is --OCH2CH3 ; R2, Z and Z1 are hydrogen; and X and Y are H3CO--.

Provenance & Evidence