Sodium Hydroxide → HCID 70067562, compound

Participants

Reaction Steps

(3S)-1-[N-[3-(Benzoylamino)-2-hydroxy-4-phenylbutyl]-N-[(phenylmethoxy)carbonyl]-L-alanyl]-L-proline, phenylmethyl ester from Example 1 (g) is treated with sodium hydroxide to give (3S)-1-[N-[3-(benzoylamino)-2-hydroxy-4-phenylbutyl]-N-[(phenylmethoxy)carbonyl]-L-alanyl]-L-proline. Treatment with the reagent listed below in Col. I gives the N-protected product shown in Col. II. Removal of the N-protecting group by hydrogenolysis with palladium on carbon catalyst in the presence of hydrochloric acid gives the product shown in Col. III. ##STR183##

Provenance & Evidence