HCID 178419259, compound → HCID 178498199, compound

HRID 1981418Notes

Reaction equation

HRID 1981418 reaction equation
Br.Br.[NH2:3][CH2:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20](=[NH:22])[NH2:21])=[CH:16][C:15]=2[C:23]([O:25][CH3:26])=[O:24])=[O:12])[CH2:7][CH2:6]1>C(O)C>[NH2:3][CH2:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20](=[NH:21])[NH2:22])=[CH:16][C:15]=2[C:23]([O:25][CH3:26])=[O:24])=[O:12])[CH2:7][CH2:6]1

Participants

3

Reactant 1

HCID 178419259HCID 178419259, compound

Product 1

HCID 178498199HCID 178498199, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 9.0 ml of a 30% hydrogen bromide-acetic acid mixture, was added 2.8 g of 4-amidino-2-methoxycarbonylphenyl trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate methanesulfonate. The mixture was stirred for one hour at room temperature, meanwhile the crystals dissolved in a few minutes, forming a uniform yellow solution. The reaction mixture was mixed with ethyl ether, and the crystals were collected by filtration, washed with ethyl ether, and dried to obtain 3.1 g a dried product. The dried product was recrsytallized from ethanol to obtain 1.3 g of colorless granular crystals of 4-amidino-2-methoxycarbonylphenyl trans-4-aminomethylcyclohexane carboxylate dihydrobromide.

Sources & evidence

ORD record
ord-f207d7b5ef1e4a1a894dabb06503de22
Source dataset
uspto-grants-1985_04
Patent number
US04514416

Reaction notes

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