Ammonia → 4-HYDROXY-3-METHOXY-BENZAMIDINE

HRID 1981423Notes

Reaction equation

HRID 1981423 reaction equation
[NH3:1].Cl.CO[N:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([O:14][CH3:15])[CH:8]=1>CO>[C:6]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([O:14][CH3:15])[CH:8]=1)(=[NH:5])[NH2:1]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 136387256HCID 136387256, compound

Product 1

HCID 44059954-HYDROXY-3-METHOXY-BENZAMIDINE

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 100 ml of anhydrous methanol and about 50 ml of liquid ammonia, was added slowly 8.7 g of 4-methoxyiminomethyl-2-methoxyphenol hydrochloride. The mixture was stirred overnight at room temperature. The colorless crystals precipitated from the reaction mixture were collected by filtration, washed thoroughly with methanol, and dried to obtain 7.4 g of 4-amidino-2-methoxyphenol.

Workup

  1. customThe colorless crystals precipitated from the reaction mixture
  2. filtrationwere collected by filtration
  3. washwashed thoroughly with methanol
  4. customdried

Sources & evidence

ORD record
ord-9fde3508b3b4405e96ad8ca2694bb74a
Source dataset
uspto-grants-1985_04
Patent number
US04514416

Reaction notes

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