Sodium borohydride → Triapenthenol

Participants

Reaction Steps

26 g (0.1 mol) of (E)-1-cyclohexyl-4,4-dimethy-2-(1,2,4-triazol-1-yl)-pent-1-en-3-one are taken up in 200 ml of methanol, and 4.5 g of sodium borohydride are added in portions, while stirring and cooling. When the reaction has ended, the reaction mixture is brought to pH 6 and concentrated. The residue is taken up 200 ml of methylene chloride, the mixture is washed with saturated sodium bicarbonate solution, dried over sodium sulphate and filtered and the filtrate is concentrated. The residue is recrystallised from petroleum ether. 14.5 g (55% of theory) of racemic (E)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene of melting point 131° C. are obtained.

Provenance & Evidence