N-[5-Carbamimidamido-1-(4-nitroanilino)-1-oxopentan-2-yl]-1-[N-(4-methylbenzene-1-sulfonyl)glycyl]pyrrolidine-2-carboximidic acid--hydrogen chloride (1/1) → HCID 16220038, compound

HRID 1981480Notes

Reaction equation

HRID 1981480 reaction equation
CC1C=CC(S(NCC(N2[C@H](C(N[C@H](C(NC3C=CC([N+]([O-])=O)=CC=3)=O)CCCN=C(N)N)=O)CCC2)=O)(=O)=O)=CC=1.Cl.[CH3:44][C:45]1[CH:50]=[CH:49][C:48]([S:51]([NH:54][CH2:55][C:56]([N:58]2[CH:62]([C:63]([NH:65][CH:66]([C:72]([NH:74][C:75]3[CH:80]=[CH:79][C:78]([N+:81]([O-:83])=[O:82])=[CH:77][CH:76]=3)=[O:73])[CH2:67][CH2:68][CH2:69][CH2:70][NH2:71])=[O:64])[CH2:61][CH2:60][CH2:59]2)=[O:57])(=[O:53])=[O:52])=[CH:47][CH:46]=1>>[NH:54]([S:51]([C:48]1[CH:47]=[CH:46][C:45]([CH3:44])=[CH:50][CH:49]=1)(=[O:53])=[O:52])[CH2:55][C:56]([N:58]1[CH2:59][CH2:60][CH2:61][C@H:62]1[C:63]([NH:65][C@H:66]([C:72]([NH:74][C:75]1[CH:80]=[CH:79][C:78]([N+:81]([O-:83])=[O:82])=[CH:77][CH:76]=1)=[O:73])[CH2:67][CH2:68][CH2:69][CH2:70][NH2:71])=[O:64])=[O:57]

Participants

3

Reactant 2

HCID 123649N-[5-Carbamimidamido-1-(4-nitroanilino)-1-oxopentan-2-yl]-1-[N-(4-methylbenzene-1-sulfonyl)glycyl]pyrrolidine-2-carboximidic acid--hydrogen chloride (1/1)2×HCID 4169197HCID 4169197, compound2×

Product 1

HCID 16220038HCID 16220038, compound

Procedure

The activity of two samples treated in parallel according to Example 1 was determined with Chromozym TH and with an equimolar amount of Chromozym PL. With Chromozym PL, there was found ΔE/h=0.052 and with Chromozym TH ΔE/h=0.048.

Workup

  1. additionThe activity of two samples treated

Sources & evidence

ORD record
ord-4c107a973dae4d46909aba685e19c43b
Source dataset
uspto-grants-1986_06
Patent number
US04592997

Reaction notes

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