Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 2-Amino-6-m-fluorophenyl-1,3-oxazine-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Ethyl 3-(3-fluorophenyl)-3-oxopropanoate | HCID 2063904 | — |
| 반응물 | Oxazine | HCID 12313776 | — |
| 반응물 | HCID 178485225 | HCID 178485225 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Amino-6-m-fluorophenyl-1,3-oxazine-4-one | HCID 13370935 | — |
반응 단계
To 16.6 g (0.597M) of methylthiopseudourea sulfate is added 66 ml of H2O+13.0 g of KOH. With vigorous stirring, 20 g (71.9 mM) of ethyl-m-fluorobenzoylacetate is added and the reaction mixture is allowed to stir, at ambient temperature, for 18 hours. The solids are filtered and washed well with H2O followed by diethylether. The crude title compound is dried at 60° C. in a vacuum over to yield 16.0 g (>100 percent). To 6.8 g of crude powdered oxazine is added 100 ml of H2O and heated to 70° C., cooled, filtered and washed solids. Yield of 2-amino-6-m-fluorophenyl-1,3-oxazine-4-one of 3.60 g (53 percent of rec. yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04593030 |
| 출처 데이터셋 | uspto-grants-1986_06 |
| ORD ID | ord-651f6cfe4c9340fda8634c51fe307646 |
| 출처 메모 | uspto-grants-1986_06 |