Methyl acetoacetate → HCID 13505726, compound

Participants

Reaction Steps

To compound (3d) (8.0 g, 49.3 mmol) in anhydrous methanol (50 ml) was added methyl 3-aminocrotonate (5.68 g, 49.3 mmol), methyl acetoacetate (5.72 g, 49.3 mmol), and concentrated ammonium hydroxide (1 ml) and the resulting solution heated at reflux under nitrogen for 4 days. The solvent was removed in vacuo and the residual material triturated with ether (20 ml) to give compound (3e) as a pale, yellowish solid, mp 141°-143°.

Provenance & Evidence