Butyl bromide → HCID 23318987, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-(6-(N-imidazolyl)hexyl)oxy-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one in dry dimethylformamide is added sodium hydride (1.05 equivalents). The mixture is stirred at 60° C. for 30 minutes to give a homogeneous solution. 1-bromobutane (1.1 equivalents) is added via a syringe after which the mixture is stirred at 60° C. for 2 hours. The solvent is evaporated and the residue taken up in ethyl acetate which is washed with saturated brine, dried and filtered. Evaporation of the solvent affords 7-(6-(N-imidazolyl)hexyl)oxy-1-butyl-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one.

Provenance & Evidence