Sulfuric Acid → HCID 135668093, compound

HRID 1981566Notes

Reaction equation

HRID 1981566 reaction equation
C(O)(=O)C.[N:5]1([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[N:23]=[C:22]2[NH:27][C:28](=[O:30])[CH2:29][N:21]2[CH2:20]3)[CH:9]=[CH:8][N:7]=[CH:6]1.[S:31](=[O:35])(=[O:34])([OH:33])[OH:32]>O>[S:31]([OH:35])([OH:34])(=[O:33])=[O:32].[N:5]1([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[N:23]=[C:22]2[NH:27][C:28](=[O:30])[CH2:29][N:21]2[CH2:20]3)[CH:9]=[CH:8][N:7]=[CH:6]1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 135668126HCID 135668126, compound

Product 1

HCID 135668093HCID 135668093, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

7-(6-(N-imidazolyl)hexyl)oxy-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one acetate (1.0 g) is dissolved in 50 ml water containing a stoichiometric equivalent of sulfuric acid, and the solution evaporated to dryness. The product is suspended in ethanol and filtered, air dried and recrystallized from methanol/acetone to yield 7-(6-(N-imidazolyl)hexyl)oxy-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one sulfate.

Workup

  1. customthe solution evaporated to dryness
  2. filtrationfiltered
  3. customair dried
  4. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-874da132df284f5789ea346668afc5d3
Source dataset
uspto-grants-1986_06
Patent number
US04593029

Reaction notes

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