HCID 23319622, compound → HCID 13575823, compound

HRID 1981571Notes

Reaction equation

HRID 1981571 reaction equation
COC([CH:5]1[C:9]2([C:13]3[CH:14]=[CH:15][CH:16]=[C:17]4[S:18][C:19]5[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=5[N:11]([C:12]=34)[C:10]2=[O:25])[C:8](=[O:26])[NH:7][C:6]1=[O:27])=O>C(O)(=O)C>[C:10]1(=[O:25])[N:11]2[C:12]3[C:17]([S:18][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=42)=[CH:16][CH:15]=[CH:14][C:13]=3[C:9]21[CH2:5][C:6](=[O:27])[NH:7][C:8]2=[O:26]

Participants

3

Reactant 1

HCID 23319622HCID 23319622, compound

Product 1

HCID 13575823HCID 13575823, compoundYield 73.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The above product from part (a) (2.2 g, 0.0058 mole) was refluxed in acetic acid (20 ml) for 9 hours. After cooling, the resultant precipitate was collected by filtration and recrystallized from acetic acid-DMSO to afford 1.38 g (73.8%) of spiro[pyrrolidine-3,2'-pyrrolo[3,2,1-kl]phenothiazine]-1',2,5-(2'H)-trione, mp. above 300° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resultant precipitate was collected by filtration
  3. customrecrystallized from acetic acid-DMSO

Sources & evidence

ORD record
ord-a0f77f54941845be85251af1417fe975
Source dataset
uspto-grants-1986_06
Patent number
US04593092

Reaction notes

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