Pyridine → HCID 13607936, compound

Participants

Reaction Steps

A mixture of 5-acetyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridinecarboxylic acid (J. A. Berson and E. Brown, J. Amer. Chem. Soc., 77, 444 (1955), 2.34 g), hydroxylamine hydrochloride (0.71 g), pyridine (0.81 g), and ethanol (50 mL)) was heated under reflux on a steam bath for 4 hours, then evaporated on a rotary evaporator. The residue was dissolved in hot methanol, and the solution was filtered. The filtrate was concentrated on a rotary evaporator, and chilled in an ice-bath to cause a separation of a precipitate. The precipitate was collected on a filter, and recrystallized once more from methanol to give the titled product (0.1 g), mp 211.5°-212.5° C.

Provenance & Evidence