HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → Benzyl-3-oxo-2-(phenylmethyl)-1-piperazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-Benzylpiperazin-2-one | HCID 13520416 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Benzyl-3-oxo-2-(phenylmethyl)-1-piperazinecarboxylate | HCID 13520417 | — |
Reaction Steps
Benzyl chloroformate (8.5 g.) is added to a stirred mixture of 3-(phenylmethyl)piperazinone (XXIX, Example 62, 6.8 g.), chloroform (75 ml.), and saturated sodium bicarbonate solution (20 ml.). After 30 minutes the chloroform phase is separated, washed twice with water, and concentrated. The residual oil is crystallized from ethyl acetate-SSB and then ethyl acetate again to give the title compound, m.p. 125°-127.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04593098 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-bab77e3fc28749f1903d16ef98f79847 |
| Source note | uspto-grants-1986_06 |