Acetic Acid → HCID 178472877, compound

Participants

Reaction Steps

A suitable reaction vessel was charged with 0.385 mol of ethyl acetoacetate and 0.87 mol of acetic acid and cooled in an ice bath. A solution of 0.435 mol of sodium nitrite in 50 ml of water was added dropwise to the reaction mixture over a period of about 30 minutes, and the resultant reaction mixture was stirred until its color went from clear to light orange. The ice bath was then removed and stirring continued for an additional two hours, another 140 ml of water being added 30 minutes into this two-hour stirring period. Work-up of the reaction mixture resulted in the isolation of ethyl 2-oximinoacetoacetate in a 95% yield.

Provenance & Evidence