HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Ethyl 2-acetamido-3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Reactant | HCID 178472877 | HCID 178472877 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Ethyl 2-acetamido-3-oxobutanoate | HCID 224840 | 92.3% |
Reaction Steps
A Parr flask was charged with 0.2 mol of ethyl 2-oximinoacetoacetate, 0.4 mol of acetic anhydride, 45 psi of hydrogen, and a mixture of 0.25 g of 5% palladium-on-carbon and 0.4 g of 10% palladium-on-carbon and shaken for about 22 hours. Work-up of the resultant reaction mixture provided a 92.3% yield of ethyl 2-acetamidoacetoacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04593118 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-47f2e7cec1074d90a983d33959783130 |
| Source note | uspto-grants-1986_06 |