Potassium Hydroxide → 2-Acetamido-3-aminobutanoic acid
Reaction equation
[C:1]([NH:4][CH:5]([CH:11]([NH2:13])[CH3:12])[C:6]([O:8]CC)=[O:7])(=[O:3])[CH3:2].[OH-].[K+]>CO>[C:1]([NH:4][CH:5]([CH:11]([NH2:13])[CH3:12])[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 23 °C
Procedure
Five grams of ethyl 2-acetamido-3-aminobutyrate were dispersed in 10 ml of cold methanol, after which 1.51 g of potassium hydroxide in 15 ml of methanol were added. The mixture was stirred in an ice bath and then allowed to warm to 23° C. over a period of 18 hours. The solvent was removed at reduced pressure, and the residue was dissolved in a minimum of warm water and adjusted to a pH of 6.5 with hydrochloric acid. Upon cooling, crystals of 2-acetamido-3-aminobutyric acid were formed in a 95% yield.
Workup
- customThe solvent was removed at reduced pressure
- dissolutionthe residue was dissolved in a minimum of warm water
- temperatureUpon cooling
Sources & evidence
- ORD record
- ord-93ec49bf76a64ada9ad588bd7047da24
- Source dataset
- uspto-grants-1986_06
- Patent number
- US04593118
Reaction notes
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